Navigation und Service

Understanding how endocrine disruptors and chemical mixtures of concern target the immune system to trigger or perpetuate disease (ENDOMIX)

01/2024-12/2027

Funding programme / funding institution: European Union

Grant number: Grant Agreement 101136566

Project description:

Goal of the project is to determine the real exposure to endocrine acting chemicals (EDCs) in different population subgroups, to understand their mode of action, to identify new relevant EDCs mixtures, and, by providing the gained knowledge, to contribute to a reduction of exposure to those chemicals. For this purpose, ENDOMIX is pursuing an interdisciplinary approach covering the entire chain from population-based date to a mechanistic understanding of the mode of action at the cell and target organ levels. By combining population-based cohort data over the entire lifetime, high throughput screening and modeling to identify new mixtures, in vitro cell cultures including barrier and organoid models, in vivo models, omics and computer-based approaches, ENDOMIX will deliver evidence-based guidance and recommendations for politics and citicens. Analysis of exposure data will additionally consider social aspects (lifestyle, nutrition, living environment). ENDOMIX focuses on immune cells and their downstream signaling pathways in other organs for the identification of molecular mechanisms of EDCs, in order to understand the initial stages of adverse/pathological effects in different target organs (respiratory diseases and allergies, cariometabolic health, reproductive health, diabetes, adipositas, autoimmune diseases).

Coordination: Helmholtz-Zentrum für Umweltforschung

Project partners:

• French National Institute of Health and Medical Research, Frankreich
• Barcelona Institute for Global Health, Spanien / Barcelona
• Imperial College London, Vereinigtes Königreich
• Universität Utrecht, Niederlande
• Erasmus University Medical Center, Niederlande / Rotterdam
• Masaryk-Universität, Tschechien
• Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Deutschland
• EIBIR gemeinnützige GmbH zur Förderung der Erforschung der biomedizinischen Bildgebung, Österreich

Up