DMELshort forDerived Minimum Effect Level - Derived Minimum Effect Level
If no DNELshort forDerived No Effect Level can be derived for a substance because no threshold value exists for the corresponding toxicological effect (e.g. for genotoxic carcinogens) then, according to the ECHA’s Guidance on information requirements and chemical safety assessment, chapter R.8: ‘Characterisation of dose [concentration]-response for human health’, a DMELshort forDerived Minimum Effect Level should be derived to assess the chemical in terms of the EU REACH Regulation. This value corresponds to a level of exposureExposureTo glossary that results in a very low risk to the general population. The value is usually specified in mgshort formilligram/kgshort forkilogram body weight per day.