Frequently asked questions on Caffeine and Foods Containing Caffeine, including Energy Drinks

Caffeine stimulates the cardiovascular and central nervous systems, which in moderate doses enhances physical performance as well as the mental alertness.

With high intake quantities of caffeine, adverse effects can occur such as increased nervousness and excitability, sleeplessness, sweating attacks and palpitations. The occurrence of adverse effects, however, depends strongly on individual sensitivity to caffeine and the ingested dose. Over a longer period of time, excessive caffeine consumption can lead to cardiovascular problems such as high blood pressure. In pregnant women increased caffeine intake over a longer period can lead to reduced foetus growth.

The EFSAshort forEuropean Food Safety Authority estimated in 2015 the quantities of caffeine which are safe for the general healthy population. Accordingly, intake quantities of up to 200 milligrams (mgshort formilligram) as a single dose or the same quantity consumed within a short period of time (corresponding to 3 mgshort formilligram per kilogram (kgshort forkilogram) of body weight) do not give rise to concerns about adverse health effects for the general healthy population. Spread over the day, an intake of up to 400 mgshort formilligram caffeine is regarded as safe for healthy adults.

Regarding pregnant or lactating women habitual caffeine consumption up to 200 mgshort formilligram per day does not give rise to safety concerns for the foetus or breastfed infants. According to EFSAshort forEuropean Food Safety Authority, for children and adolescents the information available is insufficient to derive a safe caffeine intake. EFSAshort forEuropean Food Safety Authority considers that caffeine intakes of no concern derived for acute caffeine consumption by adults (3 mgshort formilligram per kgshort forkilogram body weight per day) may serve as a basis to derive single doses of caffeine and daily caffeine intakes of no concern for children and adolescents.

No, the derived intake quantities of caffeine calculated by the EFSAshort forEuropean Food Safety Authority apply only to the general healthy population and specific sub-groups thereof, such as children, adolescents, adults, older people, pregnant and lactating women and people performing physical exercise.

The EFSAshort forEuropean Food Safety Authority report did not assess possible adverse effects of caffeine for persons suffering from diseases or complaints and/or persons who in combination with caffeine take drugs or medication or consume large quantities of alcohol. Therefore, the caffeine quantities regarded as safe do not apply to these groups of persons. According to the EFSAshort forEuropean Food Safety Authority, moderate alcohol consumption (blood alcohol concentration up to 0,8 per mille) has no influence on the safety of single caffeine doses of up to 200 mgshort formilligram (dose regarded as safe for healthy adults).

Drinks containing more than 150 mgshort formilligram of caffeine per litre must bear the following advice: “Increased caffeine content. Not recommended for children and pregnant or lactating women”. This note must be positioned in the same field of vision as the name of the beverage followed by a reference to the caffeine content. The exceptions to this rule are coffee and tea and/or beverages based on coffee or tea extract with the word “coffee” or “tea” in the designation.

A comparable labelling requirement also applies to foods other than beverages to which caffeine has been added. Concerning food supplements, the caffeine content per recommended daily dosage has to be indicated.

Energy drinks are refreshing drinks containing in addition to caffeine one or more of the substances taurine, glucuronolactone and inositol. They are advertised as having the ability to enhance concentration and physical performance.  

Energy drinks should not be confused with hypotonic or isotonic sports drinks containing carbohydrates which are intended to compensate the loss of energy, water and electrolyte resulting from physical activity.

Taurine occurs naturally in the human body and originates as a metabolite mainly from the amino acid cysteine. Taurine is said to play an important role in brain development as well as the stabilisation of the cell membrane. Taurine is ingested with food, in particular by fish and meat. Intake via a normal diet varies between 10 and 400 mgshort formilligram per day. In animal studies, intake quantities of up to 1,000 mgshort formilligram of taurine per kgshort forkilogram of body weight per day showed no harmful effects.

According to EFSAshort forEuropean Food Safety Authority, taurine in the customary energy drink concentrations (4,000 mgshort formilligram per litre) has no influence on the safety of single caffeine doses of up to 200 mgshort formilligram (dose regarded as safe for healthy adults). By consuming three conventional cans of energy drinks à 250 mlshort formillilitre, however, as much as 240 mgshort formilligram of caffeine is ingested. The studies conducted to date on the matter whether additional taurine intake enhances physical and mental performance capacity are contradictory and often of poor scientific quality and therefor no clear evidence has been produced to date for this reason.

Glucuronolactone is an ester of glucuronic acid which is also formed naturally in the body as a metabolite of glucose. Glucuronolactone is an important component of connective tissue which is only ingested with food in small quantities (1 to 2 mgshort formilligram per day). In animal studies, intake quantities of up to 1,000 mgshort formilligram of glucuronalactone per kgshort forkilogram of body weight per day showed no harmful effects.

According to EFSAshort forEuropean Food Safety Authority, glucuronalactone in the customary energy drink concentrations (2,400 mgshort formilligram per litre) has no influence on the safety of single caffeine doses of up to 200 mgshort formilligram (dose regarded as safe for healthy adults). By consuming three conventional cans of energy drinks à 250 mlshort formillilitre, however, as much as 240 mgshort formilligram of caffeine is ingested. The data available to date give no indication that the customary doses of glucuronolactone in energy drinks enhance physical and mental performance capacity.

Conventional energy drinks contain 320 mgshort formilligram of caffeine per litre. The table shows how much caffeine is ingested with other beverages containing caffeine compared to energy drinks.

All values are approximations as the caffeine content can fluctuate.

Source: modified from EFSAshort forEuropean Food Safety Authority (2015)

Unwanted effects of energy drinks are presumably caused mainly by the caffeine. If ingested in high quantities, caffeine can cause increased nervousness and excitability, sleeplessness, outbreaks of sweating and palpitations. Over a longer period of time, excessive caffeine consumption can lead to cardiovascular problems, such as increased blood pressure.

No health impairments are to be expected with moderate consumption of energy drinks under observation of the directions for use. 80 mgshort formilligram of caffeine are ingested through the consumption of one conventional energy drink à 250 mlshort formillilitre with a caffeine content of 320 mgshort formilligram per litre. This caffeine quantity is regarded as safe for healthy adults and is the equivalent of roughly one cup of coffee.

If three cans of energy drinks (equivalent to 240 mgshort formilligram caffeine) are consumed within a short period of time, however, the single caffeine dose of 200 mgshort formilligram which is regarded as safe for healthy adults is exceeded. Health risks can therefore result if these drinks are consumed in larger quantities so that high levels of caffeine are ingested within a short period of time. With a high consumption of energy drinks, in particular the simultaneous consumption of larger quantities of alcohol and/or extensive physical activity can have additional negative effects on the cardiovascular system. According to EFSAshort forEuropean Food Safety Authority, moderate alcohol consumption (blood alcohol concentration of up to 0,8 per mille) has no influence on the safety of single caffeine doses of up to 200 mgshort formilligram (dose regarded as safe for healthy adults).

The “Event-Related Survey of High Consumers of Energy Drinks“ conducted by the BfRshort forGerman Federal Institute for Risk Assessment in 2013 shows that visitors to clubs as well as music and sports events to some extend consume considerable amounts of energy drinks. On average, the high consumers drank approx. 1 litre of energy drinks either straight or mixed with alcoholic beverages when dancing in clubs. In 5 % of these cases, more than 2.75 litres were consumed. (http://www.bfr.bund.de/cm/350/event-related-survey-of-high-consumers-on-energy-drinks.pdf)

A survey commissioned by the EFSAshort forEuropean Food Safety Authority in 2012 on the consumption of energy drinks in 16 EU countries showed that roughly 16 % of the adolescents and 6 % of the adults questioned drink three and more cans of energy drink at a single session. Assuming that these were conventional cans, the single caffeine dose that is regarded as safe - 200 mgshort formilligram for healthy adults - is exceeded. The consumption habits in the EU member states, however, can be very different.

According to EFSAshort forEuropean Food Safety Authority, moderate alcohol consumption (blood alcohol concentration of up to 0,8 per mille) has no influence on the safety of single caffeine doses of up to 200 mgshort formilligram (dose regarded as safe for healthy adults). By consuming three conventional cans of energy drinks à 250 mlshort formillilitre, however, 240 mgshort formilligram of caffeine have already been ingested.

In the view of the BfRshort forGerman Federal Institute for Risk Assessment, health risks can arise if energy drinks are consumed in larger quantities, especially in combination with larger quantities of alcohol. In the past, severe health impairments such as cardiac arrhythmias, in parts with fatal outcome, have been described in some case reports, often in combination with the simultaneous consumption of alcohol. However, no causality has yet been proven.

Energy drinks should not be confused with sports drinks, which provide above all liquid and energy in the form of water and carbohydrates. They are either hypotonic or isotonic, i.e. they have lower or identical concentrations of dissolved particles compared to blood which allow the liquid to be absorbed quickly by the body. Many sports drinks also contain caffeine as it can increase endurance performance in sports.

In general, energy drinks have a relatively high sugar concentration. This means that they provide a lot of energy for a short space of time, but the high sugar content can delay the liquid adsorption via the digestive tract. As the feeling of thirst increases with physical efforts, there is also the risk of energy drinks being consumed in larger quantities, thus resulting in high caffeine intakes. It is then possible that the effects on the cardiovascular system caused by the physical activity can be negatively intensified by the high caffeine intake.

Moderate caffeine intake in combination with physical activity is unproblematic to health. Accordingly, EFSAshort forEuropean Food Safety Authority stated that single doses of up to 200 mgshort formilligram of caffeine do not give rise to concerns about adverse health effects to healthy adults, even if consumed less than two hours before intense physical exercise.

National maximum legal limits have been in force in Germany since June 2013 for the following four ingredients:

• Caffeine: 320 mgshort formilligram per litre
• Taurine: 4,000 mgshort formilligram per litre
• Inositol: 200 mgshort formilligram per litre
• Glucuronolactone: 2,400 mgshort formilligram per litre

The exact quantity of added caffeine must be declared by the manufacturer on the packaging (label) of energy drinks. In other EU countries, different rules may apply.