Category Research project
  • Toxikologie

Understanding how endocrine disruptors and chemical mixtures of concern target the immune system to trigger or perpetuate disease

Project status
In Progress
Project start
Jan 2024
Project end
Dec 2027
Acronym
ENDOMIX
Department
Chemikalien- und Produktsicherheit
Website
https://endomix.eu/

Description and Objective

Goal of the project is to determine the real exposureExposureTo glossary to endocrine acting chemicals (EDCs) in different population subgroups, to understand their modeModeTo glossary of action, to identify new relevant EDCs mixtures, and, by providing the gained knowledge, to contribute to a reduction of exposure to those chemicals. For this purpose, ENDOMIX is pursuing an interdisciplinary approach covering the entire chain from population-based date to a mechanistic understanding of the mode of action at the cell and target organ levels. By combining population-based cohort data over the entire lifetime, high throughput screening and modeling to identify new mixtures, in vitro cell cultures including barrier and organoid models, in vivo models, omics and computer-based approaches, ENDOMIX will deliver evidence-based guidance and recommendations for politics and citicens. Analysis of exposure data will additionally consider social aspects (lifestyle, nutrition, living environment). ENDOMIX focuses on immune cells and their downstream signaling pathways in other organs for the identification of molecular mechanisms of EDCs, in order to understand the initial stages of adverse/pathological effects in different target organs (respiratory diseases and allergies, cariometabolic health, reproductive health, diabetes, adipositas, autoimmune diseases).
Type of project

Third-party funded project

Research focus

Wirkungsbezogene Analytik und Risikofrüherkennung

Organisational units and partners

Lead specialist group: Zellbasierte Teststrategien und Toxikogenomik (74)
Contact persons: Prof. Dr. Albert Braeuning, Dr. Linda Böhmert
External partner: French National Institute of Health and Medical Research, Barcelona Institute for Global Health, Imperial College London, Universität Utrecht, Erasmus University Medical Center, Masaryk-Universität, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., EIBIR gemeinnützige GmbH zur Förderung der Erforschung der biomedizinischen Bildgebung, Helmholtz-Zentrum für Umweltforschung GmbH

Funding body and grant number

Europäische Union
Grant Agreement 101136566

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