The overarching goal of NanoCommons was to connect communities in order to establish a knowledge platform/ infrastructure that organises data and data relationships and makes it accessible. Moreover, computational tools and
in silico workflows should be integrated. This aimed at supporting nanomaterial (NM) risk assessment and Safe-by-Design approaches. In the following the most important outcomes with
BfRshort forGerman Federal Institute for Risk Assessment contribution will be summarized while the final report contains a detailled description of all results.
One work focus at the
BfRshort forGerman Federal Institute for Risk Assessment was the establishment and application of bioinformatic tools for supporting nanomaterial grouping. Specifically different random forest algorithms for classification were tested on existing nano datasets. A case study could be successfully completed. Moreover, the
BfRshort forGerman Federal Institute for Risk Assessment also aimed to integrate Omics data, in particular proteomics data to support grouping.Another important focus was to establish the Advanced Nano FAIR Implementation Network (IN) within the GO FAIR initiative, in close collaboration with the EU project Gov4Nano. This implementation network worked to connect stakeholders to implement the FAIR principles in order to optimize relevant data and data bases according to the FAIR principle, rendering them findable, accessible, interoperable and re-usable. Following the launch of the AdvancedNano IN, the
BfRshort forGerman Federal Institute for Risk Assessment aimed to attract further partners and projects into the network and to generally raise awareness about the FAIR principles. For this purpose, a detailed questionnaire has been developed and circulated among various ongoing europaen and national nano-projects to get insights into specific activities of these projects to implement the FAIR principles. The received input was merged into a "Map of FAIR Activities" and was also fed into the publication, which is currently under peer review. The
BfRshort forGerman Federal Institute for Risk Assessment also continued to work on making nanoEHS proteomics data more FAIR, in colloboration with NanoInformaTIX. Typically, in the field of proteomics the original datasets are uploaded in public repositories such that they are findable and accessible. However, they are neither interoperable nor ready for reuse, as nanospecific meta-data is completely missing. Thus,
BfRshort forGerman Federal Institute for Risk Assessment developed a template to collect the nanospecific metadata, upload it in a nanospecific database (eNanoMapper) and thereby link it to the original proteomics data. In a first step, the
BfRshort forGerman Federal Institute for Risk Assessment also assessed which nanoEHS proteomics data are acessible in public repositories such as e.g. PRIDE. For those nanospecific metadata was collected and linked via the template in eNanoMapper. The publically available proteomics data are now also findable via eNanoMapper. Moreover, by linking the metadata their reuse was facilitated.