Category Research project
  • Toxikologie

Safe Food and Feed through an Integrated ToolBox for Mycotoxin Management (MyToolBox)

Project status
Completed
Project start
Mar 2016
Project end
Feb 2020
Acronym
MyToolbox
Department
Sicherheit in der Nahrungskette

Description and Objective

The aim of this EU project was to compile and develop measures, recommendations, and guidelines to reduce or avoid mycotoxin contamination in the food chain. So-called "pre-harvest" measures include possibilities during cultivation, whereas "post-harvest" measures include improved storage, sorting, and processing procedures and technologies. MyToolBox not only pursues a field-to-fork approach but also considers safe use options of contaminated batches, such as the efficient production of biofuels. The tools are to be made available to users (farmers, processers) in a portal of an app. The BfRshort forGerman Federal Institute for Risk Assessment was involved in the work package on standardisation and legislation, including preparation of a report on processing factors and mycotoxin maximum levels in food chains, particularly cereal chains. The MyToolBox Consortium comprised 23 project partners in 11 countries (www.mytoolbox.eu).

Result

The MyToolBox project partners tested several pre-harvest mycotoxin reduction strategies for farmers in view to their efficacies. These measures comprised: biopesticides and biofumigation techniques tested in field and glasshouse experiments with wheat and oats in the UK and Norway; resistance of maize cultivars against Aspergillus flavus infection tested in fields in Italy and Serbia; and newly isolated atoxigenic Aspergillus flavus strains tested in fields in Serbia. The strategies for mycotoxin reduction in maize grown in Southern Europe showed very promising results: Using resistant plant cultivars resulted in up to 98% reduction of aflatoxin B1 at normal yields, while the use of an atoxigenic strain showed aflatoxin B1 reductions of up to 73%. Biocontrol strategies for wheat and oats in the UK and Norway were optimised. These efforts were complemented by developing European models that predict deoxynivalenol contamination in wheat, and fumonisins and aflatoxin contamination in maize, up to 4 days in advance. For biofuel production recombinant enzymes were added to bioethanol production: Fumonisin B1 and zearalenone could be simultaneously degraded up to 99% and 89%, respectively, in lab-scale tests. Formation of the degradation products hydrolysed fumonisin B1 and hydrolysed zearalenone confirmed the biotransformation. To prevent post-harvest mycotoxin contaminations during storage, sensors were developed to predict potential fungal growth – and thus mycotoxin contamination – in wheat and maize stored in European silos. Their functionality and underlying algorithms were tested and improved in pilot-scale silos. By including CO2 as an early-warning parameter, zearalenone contamination in wheat and aflatoxin B1 contamination in maize could be forecasted 3–5 days earlier than using only temperature-sensitive sensors. These efforts were complemented by developing similar prediction models for peanuts stored in large-scale silos in China. Evaluating milling and baking techniques provided encouraging results for food producers and regulators: Different sorting, milling and micronisation techniques were studied and combined to reduce deoxynivalenol (DON) contamination in the final product. The optimum balance of low DON at high fibre content was achieved by using the medium bran fraction combined with hammer milling and sieving sifter, resulting in a final product in which DON levels are well below the maximum limits and total dietary fibre is significantly higher than in standard whole-wheat products. DON transformation during baking was assessed by using a 12C/13C labelling LC-HRMS metabolomics approach, pioneering a full mass balance of DON degradation during thermal processing: DON degraded by 6% in crackers, 5% in biscuits and 2% in bread, isoDON (1.3–3.9%) being the major degradation product. In vitro translation experiments indicate isoDON being less toxic than DON. The project results in optimising processing procedures for mycotoxin mitigation were taken into account in the report of the BfRshort forGerman Federal Institute for Risk Assessment on processing factors in cereal food chains and recommendations for regulators. Within MyToolBox, also a novel sorting system for dried figs based on a combination of optical sorting technologies and algorithms was developed. The prototype was demonstrated to end users in October 2019, and achieved an increased accuracy of up to 80 % under UV light. Overall, the MyToolBox e-platform was launched officially on February 28, 2020: Besides including the real-time forecasting of mycotoxins in fields and silos, available information such as Good Agricultural Practices, sampling schemes, scenarios for cropping seasons, regulations, etc. were analysed, combined and transformed into easy-to-understand text to ensure that end-users all along the food and feed chain find suitable information – informed and tested particularly by focus-group meetings with potential end-users held in the Netherlands, UK, Serbia, Italy, Norway and China.
Type of project

Third-party funded project

Research focus

Forschung zur Sicherheit nationaler und internationaler Warenketten

Organisational units and partners

Lead specialist group: Zusatzstoffe in Lebens- und Futtermitteln (56)
Contact persons: Dr. Carsten Fauhl-Hassek
External partner: Universität für Bodenkultur Wien

Funding body and grant number

Europäische Union
Grant agreement No 678012