Category Research project
  • Alternativmethoden zum Tierversuch
  • Expositionsschätzung
  • Toxikologie

RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs

Project status
In Progress
Project start
Jun 2021
Project end
Nov 2026
Acronym
RISK-HUNT3R
Department
Deutsches Zentrum zum Schutz von Versuchstieren und experimentelle Toxikologie
Website
https://www.risk-hunt3r.eu/

Description and Objective

Science and society are increasingly demanding a paradigm shift towards chemical safety and risk assessment without using animals. In addition to growing ethical concerns around the use of animal studies, there is the fundamental need to address all potential health effects relevant and specific to humans. In addition, due to increasing regulatory demands, the limited laboratory capacity and high costs of animal-based testing is becoming a hurdle for the provision of all desired information requirements for chemicals safety assessment. The project will develop, validate and implement integrated approaches to lead the way towards next-generation risk assessment (NGRA). Innovative mechanism-based new approach methods (NAMs) will exclusively be in vitro and in silico and relevant for human health. Through systematic and iterative evaluation of its NAM toolbox, the project will optimize a strategy to assess chemical exposureExposureTo glossary, toxicokinetics, and toxicodynamics. RISK-HUNT3R will provide a full sustainable framework for NGRA that is human-relevant, fully based on non-animal approaches, and fit for implementation through engagement with chemical safety regulators.
Type of project

Third-party funded project

Areas of research

Moderne Methoden in der Toxikologie / Alternativmethoden zum Tierversuch

Organisational units and partners

Lead unit: Prüf- und Bewertungsstrategien von Pestiziden (66)
Involved BfR partners: Chemikalien- und Produktsicherheit, Sicherheit von Pestiziden
External partner: ARTTIC S.A.S., National Institute For Public Health and The Environment, BASF SE, Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Universität Uppsala, Certara, Universität Konstanz , Hospital del Mar Medical Research Institute Foundation, National Institute of Health and Medical Research, Liverpool John Moores University, Edelweiss Connect GmbH, European Molecular Biology Laboratory, DTU National Food Institute, BioDetection Systems, Steinbeis-Transferzentrum CAAT-Europe an der Universität Konstanz, Universität Leiden

Funding body and grant number

Europäische Union
Grant Agreement 964537

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