Category Research project
  • Toxikologie

PARC Hazard characterization and closing data gaps of emerging mycotoxins (Part II)

Project status
In Progress
Project start
May 2026
Project end
Jan 2029
Acronym
PARC Natural toxins II
Department
Chemikalien- und Produktsicherheit
Website
https://www.eu-parc.eu/

Description and Objective

Emerging mycotoxins are non-regulated fungal toxins frequently occurring in food and feed, but their toxicological properties and contribution to overall dietary exposureExposureTo glossary remain insufficiently characterized. While regulatory limits exist for well-studied mycotoxins, significant data gaps remain for emerging compounds such as Alternaria toxins, enniatins (ENNs), beauvericin (BEA), and selected trichothecenes. As a continuation of the Natural Toxins I project, Natural Toxins II aims to generate regulatory-relevant in vitro data to address remaining knowledge gaps for Alternaria toxins, ENNs, and BEA, with a particular focus on mixture toxicity under realistic co-exposure scenarios. In addition, the project investigates interactions with biological barriers, including the intestinal, placental, and blood–brain barriers. Furthermore, the project evaluates the toxicological properties of additional emerging mycotoxins, including nivalenol (NIV), moniliformin (MON), diacetoxyscirpenol (DAS), fusarenon-X (FUS-X), and fusaric acid (FA), focusing on genotoxicity, immunotoxicity, modeModeTo glossary of action, and biotransformation. The generated data will support future hazard and risk assessment processes and contribute to evidence-based regulatory decision-making regarding food and feed safety.
Type of project

Third-party funded project

Research focus

Alternativmethoden zum Tierversuch / Gesundheit von Mensch, Tier und Umwelt (One Health) / Internationale Zusammenarbeit / Moderne Methoden in der Toxikologie / Wirkungsbezogene Analytik und Risikofrüherkennung

Organisational units and partners

Lead specialist group: Zellbasierte Teststrategien und Toxikogenomik (74)
Contact persons: Dr. Anne-Cathrin Behr
External partner: Universität Wien, French Agency for Food, Environmental and Occupational Health & Safety , Benaki Phytopathological Institute, Austrian Institute of Technology, Universität Navarra, National Institute of Health Dr. Ricardo Jorge, Norwegian Institute of Marine Research, Universität Konstanz , Sciensano, Italian National Institute of Health, Norwegian Veterinary Institute

Funding body and grant number

Europäische Union
Grant Agreement 101057014

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