Category Research project
  • Alternativmethoden zum Tierversuch

Humanization of a neurosphere model of intrauterine growth restricted neurodevelopment.

Project status
In Progress
Project start
Jun 2025
Project end
May 2028
Acronym
Neuro-IUGR
Department
Deutsches Zentrum zum Schutz von Versuchstieren und experimentelle Toxikologie
Website
https://www.bf3r.de/en/research/third-party-funded-projects/

Description and Objective

The aim of this project is to establish a human neurosphere disease model that mimics the neurodevelopmental changes induced by intrauterine growth restriction (IUGR). This model will be used for two purposes: to better characterize the fundamental processes of IUGR-affected neurodevelopment and to test the efficacyPositive Predictive ValueTo glossary and safety of novel neuroprotective therapies. The project will create a model that will allow for the evaluation of neurodevelopmental changes caused by IUGR in basic neurogenetic functions without the use of laboratory animals. This means that we will replace the current animal model, which requires in vivo induction of IUGR through surgery or dietary restriction, with a human cell-based in vitro method.
Type of project

Third-party funded project

Research focus

Alternativmethoden zum Tierversuch

Organisational units and partners

Lead specialist group: Zentralstelle zur Erfassung und Bewertung von Ersatz- und Ergänzungsmethoden zum Tierversuch (91) External partner: Stiftung Tierärztliche Hochschule Hannover

Funding body and grant number

Bundesministerium für Bildung und Forschung
03LW0694K

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