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Associations between internal exposure to perfluorinated substances (PFAS) and the risk of cardiovascular diseases and type 2 diabetes in the EPIC-Potsdam study
04/2023-03/2026
Funding programme / funding institution: Deutsche Forschungsgemeinschaft e. V. (DFG) Bonn - Deutschland
Grant number: ME 6150/1-1
Project homepage: -
Project description:
Per- and polyfluoroalkyl substances (PFAS) are a complex group of man-made chemicals with unique water- and oil-repellent properties. They have been used for decades in the manufacture of numerous consumer products, such as non-stick cookware, breathable textiles and food packaging. Consumption of food and drinking water is the main route of human exposure. Based on the observed associations between the blood concentration of PFAS and blood lipid levels (especially LDL cholesterol), it is suspected that PFAS may play a role in the risk of cardiovascular diseases. The association with the risk of type 2 diabetes is also discussed. This study aims to investigate the associations between baseline concentrations of PFOS/PFOA and other perfluorinated compounds in the blood and the risk of developing myocardial infarction, stroke and/or heart failure and type 2 diabetes during follow-up in a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study (n=3000).
Project partners
- Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE) - Deutschland
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