Unit Product Analytics

The ‘Product Analytics‘ unit engages in the development of analytical methods for the chemical characterization of consumer products and commodities. The main goal is to evaluate the human exposureClose dialogexposureExposureTo glossary towards substances from such products in order to facilitate an exposure-based risk assessment.

On the one hand, the analytical methods aim at determining the contents of chemical compounds in consumer products. On the other hand, they should also enable an estimation of the transition of chemical compounds from products and food into the human body. This is accomplished by investigating substance migration that occurs during skin or food contact, as well as emission of volatiles that may contribute to the exposure without direct contact.

The ‘Product Analytics‘ unit possesses state-of-the-art analytical equipment that facilitates the development of specific and sensitive analytical procedures enabling the detection and quantification of a multitude of analytes. Exemplary procedures to estimateClose dialogestimateEstimateTo glossary the contribution of different exposure pathways involve

• emission chamber measurements (inhalation exposure)
• investigations employing Franz-diffusion cells (dermal exposure)
• release experiments with food contact materials into food and food simulants (oral exposure)

In addition, methods to determine the chemical integrity of products at the interface and of post-exposure metabolic changes within cells are developed. To this end, a wide range of separation and detection techniques are utilized:

• liquid and gas chromatography (including headspace modeClose dialogmodeModeTo glossary, sequential online-pyrolysis-GC and online-LC-GC, comprehensive GC×GC)
• as mass spectrometry (including sequential MSⁿ, high resolution MS, element-specific ICP-MS (also in single particle mode) and imaging MS (e.g. ToF-SIMS))
• absorption and fluorescence spectroscopy

The analytical procedures are permanently improved and validated to adopt the available methodological pool to the challenges of an ever increasing variety of materials being processed in consumer products, and to answer complex interdisciplinary scientific questions.

The ‘Product Analytics‘ unit hosts the National Reference Laboratory (NRL) for Food Contact Materials (FCMs).

The ‘Product Analytics‘ unit participates in several national and European joint research projects such as InnoMat.Life, ACE Nano, NanoAERS, Gov4Nano and NANOHEPATOX.

Co-workers within the division represent the BfRshort forGerman Federal Institute for Risk Assessment in national and international boards such as

• the §64 task forces of the Federal Office of Consumer Protection and Food Safety (BVLshort forGerman Federal Office of Consumer Protection and Food Safety)
• the EURL-NRL-network
• the AIR and NIK committees for indoor air quality guidelines
• the working groups of ECHAshort forEuropean Chemicals Agency
• the respective boards of CEN and DIN