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A sensitive LC-MS/MS method for the quantification of the plant toxins hypoglycin A and methylenecyclopropylglycine and their metabolites in cow’s milk and urine and application to farm milk samples from Germany

Hypoglycin A (HGA) and its homologue methylenecyclopropylglycine (MCPrG) are present in ackee and lychee as well as seeds, leaves, and seedlings of some maple (Acer) species. They are toxic to some animal species and humans.

The methods proposed in this work allow the sensitive and reliable quantification of HGA, MCPrG, MCPA-glycine, MCPF-glycine, and MCPA-carnitine in cow’s raw milk and urine. The methods could be used for routine monitoring of these analytes. To the best of our knowledge, this is the first validated method for the quantification of HGA, MCPrG, and their metabolites in milk.

A sensitive LC–MS/MS method for the quantification of the plant toxins hypoglycin A and methylenecyclopropylglycine and their metabolites in cow’s milk and urine and application to farm milk samples from Germany
Ahmed H. El-Khatib, Julika Lamp, Stefan Weigel
Analytical and Bioanalytical Chemistry
Published: 06 March 2023
https://doi.org/10.1007/s00216-023-04607-9

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