Category Research project
  • Alternativmethoden zum Tierversuch
  • Toxikologie

Validation of in vitro assays to study the effects of chemicals on thyroid hormone homeostasis for regulatory assessment

Project status
In Progress
Project start
Jun 2024
Project end
May 2027
Acronym
ThyreoSafe
Department
Deutsches Zentrum zum Schutz von Versuchstieren und experimentelle Toxikologie

Description and Objective

The project deals with the validation of test methods currently undergoing pre-validation for the assessment of chemicals with regard to their effect on key activities of thyroid function and thus the identification of potential endocrine disruptors. The focused assays (sodium iodide symporter, thyroperoxidase activity, deiodinase 1-3) will be finalized and validated primarily by the partners BASF and BfRshort forGerman Federal Institute for Risk Assessment, with the aim of integrating them into a test strategy. In order to ensure the long-term availability of the test systems under FRAND conditions, they are being “redeveloped” (primarily by the partners Charité, FU Berlin, and InSCREENEx) and used in validation.
Type of project

Third-party funded project

BFR research focus

Alternativmethoden zum Tierversuch

Organisational units and partners

Lead specialist group: Toxikologische Bewertungsstrategien (93)
Contact persons: Dr. Kostja Renko
External partner: BASF SE, Institut für Experimentelle Endokrinologie, Institut für Pharmazie, InSCREENEx GmbH

Funding body and grant number

Bundesministerium für Bildung und Forschung
03LW0513

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