The Environmental Exposome and Health

ENVESOME responds to the call HORIZON-HLTH-2024-ENVHLTH-02-06 on the role of air, noise, light, and hazardous waste pollution on non-communicable disease development. The project addresses the need to strengthen the knowledge available and useful to policymakers around pollution-disease associations and causal mechanisms at different phases throughout the human lifecycle. ENVESOME proposes to develop an exposome and citizen science-based framework for assessing the risks of emerging (e.g. climate change related) environmental health stressors. This will be achieved by utilising advanced human and cell biology knowledge (thus adopting a systems biology paradigm), human biomonitoring (HBM), and in vitro data for the identification and characterization of adverse outcome pathways (AOPs) and networks (AONs) associated with environmental stressors. Particular focus will be paid to intersecting toxicity pathways relevant to cardiorespiratory (CR) disease, metabolic syndrome (MD), neurotoxicity (NT) (both neurodevelopmental and neurodegenerative), immunotoxicity (IT), sleep disorders (SD), and mental health disorders (MHD). ENVESOME will account for real-life exposureClose dialogexposureExposureTo glossary assessments (including mixtures) that will come from molecular epidemiology and exposome studies. This will generate a novel integrative strategy for assessing the safety of emerging environmental pollutants (and mixtures therein) that would be readily applicable across several regulatory and policy areas including air, noise, and light pollution, and hazardous waste. ENVESOME will adopt new approach methodologies (NAMs) to improve the mechanistic understanding of the role environmental pollution plays on the onset and exacerbation of CR, MD, NT, IT, SD, and MHD. Thus, we will elucidate the main sources of environmental exposure and drivers of disease by focusing on the aforementioned policy areas.