Category Research project
  • Toxikologie

Testing of the automated and standardized workflow for the assessment of mutagenicity (bacterial gene mutation) of pesticide residue metabolites, including experts’ review of the outcome

Project status
In Progress
Project start
Sep 2025
Project end
Nov 2026
Acronym
NAMs4PestRes
Department
Sicherheit von Pestiziden

Description and Objective

In 2023 EFSAshort forEuropean Food Safety Authority launched a project to promote the use of New Approach Methods (NAMs) into the risk assessment of pesticide residues metabolites (NAMs4PestRes) through the use of the OECD QSAR toolbox, a free available in silico tool managed by ECHAshort forEuropean Chemicals Agency, to enhance connectivity of IUCLID and MetaPath and to implement embedded in silico models. The result will be an automated and standardized workflow for the assessment of mutagenicity (bacterial gene mutation) of pesticide residue metabolites to be implemented in a software application within the OECD QSAR toolbox. The workflow will consider the identity and quantity of the residues to be assessed as well as the main steps of toxicological evaluation of residue metabolites based on experimental data on the residue (if available), coverage of the metabolite by the parent compound based on the ADME properties of the parent (if applicable), and QSAR, grouping and read-across.The scheme will follow the forthcoming guidance on the residue definition. The proposed solution contributes to target and reduce the requests for experimental data by encouraging the use of alternatives to animal testing. Ultimately the proposed solution will strengthen the collaboration with ECHAshort forEuropean Chemicals Agency and Member States. Within this project, 3 case studies will be carried-out. The objectives of the call are i) to test and provide feedback on the functionality of the automated and standardized workflow for mutagenicity assessment (bacterial gene mutation) of pesticide metabolites that will be developed within the OECD QSAR toolbox and ii) t) To provide an experts’ review on the outcome of the case studies.
Type of project

Third-party funded project

BFR research focus

Moderne Methoden in der Toxikologie

Organisational units and partners

Lead specialist group: Toxikologie der Wirkstoffe und ihrer Metabolite (63)
Contact persons: Dr. Carsten Kneuer
External partner: French Agency for Food, Environmental and Occupational Health & Safety , Labor Ploufragan

Funding body and grant number

Europäische Behörde für Lebensmittelsicherheit
NP/EFSAshort forEuropean Food Safety Authority/PREV/2025-02

Our newsletters

The BfRshort forGerman Federal Institute for Risk Assessment offers you various newsletters in German and English.

Subscribe