Category Research project
  • Toxikologie

PARC - Metabolic Disruption

Project status
In the closing process
Project start
May 2022
Project end
Apr 2026
Acronym
PARC-MDC
Department
Chemikalien- und Produktsicherheit
Website
https://www.eu-parc.eu/

Description and Objective

Over the past decade, progress in endocrine disrupting chemicals (EDC) research has demonstrated that one specific adverse effect of a number of EDC is their capability to induce a lasting disruption of endogenous metabolism. These substances, referred as "metabolism disrupting chemicals" (MDC) are largely suspected to contribute to the incidence of obesity and related metabolic disorders such as type II diabetes and non-alcoholic fatty liver disease, in association with genetic factors, nutrition and lifestyle. Nowadays, more than 50 million people in Europe suffer from metabolic disorders with the role of environmental stressors (either man-made or natural chemicals) being increasingly recognized. According to WHO/IPSC (2002), specific criteria should be fulfilled for a substance to be considered as an EDC/MDC. Despite MDC are suspected to play a major role in the worldwide epidemics of metabolic disorders, there are currently no specific regulatory in vivo or in vitro tests allowing to identify their adverse effects. From a regulatory perspective, it is thus of paramount importance to validate methodologies allowing to identify and assess MDC-associated risks. This section will focus on the development of new approach methodologies (NAM) allowing to answer key regulatory needs. Specific compounds under investigation will come from the PARC priority list (BPA alternatives), other EU projects such as the EURION Cluster, and agencies like ECHAshort forEuropean Chemicals Agency or EFSAshort forEuropean Food Safety Authority.
Type of project

Third-party funded project

Areas of research

Moderne Methoden in der Toxikologie / Gesundheit von Mensch, Tier und Umwelt (One Health)

Organisational units and partners

Lead unit: Zellbasierte Teststrategien und Toxikogenomik (74)
External partner: Leibniz-Institut für Arbeitsforschung an der TU Dortmund, French National Institute for Agriculture, Food, and Environment, Universität Utrecht, Helmholtz-Zentrum für Umweltforschung GmbH, National Institute of Health and Medical Research

Funding body and grant number

Europäische Union
Grant Agreement 101057014

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