Category Research project
  • Toxikologie
  • Alternativmethoden zum Tierversuch

Humboldt CAPES-Fellowship - Liver toxicity and non-animal methods (New Approach Methods) in connection with the combination effects of pesticides

Project status
In Progress
Project start
Mar 2024
Project end
Feb 2027
Department
Sicherheit von Pestiziden

Description and Objective

Microcystins (MCs) are a group of cyclic peptide toxins produced by cyanobacteria well recognized as food and water contaminants and nowadays pose concerns as potential metabolic by-products of certain types of biological pesticides. There are approximately 286 MCs already characterized, yet less than 10% have their toxicological profiles determined. Among these, the MC-leucine arginine (MC-LR) is the most well-known, and it is classified as possibly carcinogenic to humans (Group 2B, IARC), based on liver preneoplastic lesions in animals. To gain mechanistic insight into the relationship of the MCs and the hepatocellular carcinoma (HCC) and gain mechanistic insights into the hepatocarcinogenicity of MCs, we use a data-driven approach, specifically, a Network Medicine approach based on human disease databases. We consider only experimentally validated protein-protein interactions and non-coding RNA-mediated interactions (PPI & NCI) as our underlying network.
Type of project

Third-party funded project

Research focus

Moderne Methoden in der Toxikologie / Gesundheit von Mensch, Tier und Umwelt (One Health)

Organisational units and partners

Lead specialist group: Prüf- und Bewertungsstrategien von Pestiziden (66)
Contact persons: Dr. Philip Marx-Stölting

Funding body and grant number

Alexander von Humboldt-Stiftung
1233884 - BRA - HFSTCAPES-E

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