Category Research project
  • Mikrobiologie

First research action for Medical counter measures performed in the frame of the RESILIENCE FPA consortium

Project status
In Progress
Project start
Nov 2024
Project end
Oct 2027
Acronym
RESILIENCE-R-2023
Department
Biologische Sicherheit

Description and Objective

The main objective of the project is to develop and test novel medical countermeasures against chemical, biological, radiological and nuclear threats. This is to be achieved by optimizing or expanding existing diagnostic, preventive and prophylactic measures. Due to the increasing development of resistance in bacteria, antibiotic-independent measures are becoming increasingly important in order to ensure that pathogenic bacteria can continue to be combated. As part of the project, the use of bacteriophages was classified as promising. This extends not only to the therapeutic application of these specific bacterial viruses, but also to the improvement of detection and isolation techniques. Thus, the phages are to be used either as whole biomolecules or only in parts, for example in the form of specific proteins. Of particular medical interest here is the lytic potential of phages for the biocontrol of bacteria or the isolation of specific proteins that support the fight against bacteria. In addition, specific receptor proteins are to be obtained, which are to be used as interaction sites on capture particles to improve isolation. Bacteriophages can also improve diagnostic measures as they increase the sensitivity and specificity of detection systems. The development of new instruments and therapies should shorten the time to final treatment and reduce the mortality rate for infections with highly pathogenic pathogens. However, these measures should not only be used for specific applications, but also be broadly effective, for example to combat multi-resistant pathogens (“ESKAPEE” pathogens). In the project, the proven expertise of the BfRshort forGerman Federal Institute for Risk Assessment in the field of phage research will be used as an interface for the development of new methods.
Type of project

Third-party funded project

Research focus

Gesundheit von Mensch, Tier und Umwelt (One Health) / Forschung zur Sicherheit nationaler und internationaler Warenketten / Internationale Zusammenarbeit

Organisational units and partners

Lead specialist group: Diagnostik, Erregercharakterisierung, Parasiten in Lebensmitteln (45)
Contact persons: Dr. Jens André Hammerl, Dr. Claudia Jäckel
External partner: Institut für Mikrobiologie der Bundeswehr, microphoton x GmbH, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Institut für Pharmakologie und Toxikologie der Bundeswehr, Invitris, Katholische Universität Leuven, Naturwissenschaftliche Universität Breslau

Funding body and grant number

Europäische Union
Grant Agreement 101168024

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