An overview of the overall results achieved in the HBM4EU project can be found in the following publication:
Weise,
Pshort forphosphorus., Apel,
Pshort forphosphorus. & Kolossa-Gehring, M. Human Biomonitoring for Europe (HBM4EU)—first insights into the results of the initiative. Bundesgesundheitsbl 65, 936–939 (2022).
https://doi.org/10.1007/s00103-022-03578-z :
"Abstract
Human biomonitoring measures the internal exposure of humans to chemicals from various sources, such as food, everyday objects, or the air we breathe, by analyzing blood and urine, for example. To promote and coordinate human biomonitoring in Europe, the European Human Biomonitoring Initiative (HBM4EU) was launched in 2017 and involves 30 countries, the European Environment Agency, and the European Commission. The project was completed in June 2022.Comparable and reliable exposure data were collected and consistently assessed for a wide range of environmental chemicals. Other important achievements of the initiative were the establishment of a quality assurance program, a concept for standardizing future HBM studies, a common strategy for deriving health-based guidance values (HBM-GVs), and the establishment of national committees in the partner countries. The exposure data generated are accessible via the Information Platform for Chemical Monitoring (IPCHEM) and the EU HBM Dashboard. Publications are freely available through the HBM4EU online library.Overall, the results show that exposures of the EU population to many chemicals are too high, such as phthalates and perfluorinated alkyl substances (PFAS), and that policy action is still needed. The knowledge generated in the HBM4EU project can support policymakers in improving chemical, environment, and health policies." The Work Packages (WPs) listed below contributed to the completion of various tasks. These included literature searches, preparation of scoping documents, derivation of HBM guidance values, modeling for exposure estimation, and laboratory experimental studies. The results of the WPs are available via the project's homepage at https://www.hbm4eu.eu/result/deliverables/ . WP 5: Translation of results into policy/ Tasks 5.1, 5.2, 5.3 and various other subsequently named deliverables with participation from the Food Safety, Pesticide Safety, Chemical and Product Safety and Food Chain Safety Divisions; WP 12: From HBM to exposure/ Tasks 12.1, 12.2, 12.33 and various other subsequently designated deliverables with participation from the Exposure Division; WP 14: Effect Biomarker/ Tasks 14.1, 14.2, 14.2A and various other subsequently named deliverables with participation from the Food Safety Division.Publications with
BfRshort forGerman Federal Institute for Risk Assessment participation (peer-reviewed)Physiology-based toxicokinetic modeling in the frame of the European Human Biomonitoring Initiative
Sarigiannis, D.A., Karakitsios, S., Dominguez-Romero, E., Papadaki, K., Brochot, C., Kumar, V., Schumacher, M., Sy, M., Mielke, H., Greiner, M., Mengelers, M., Scheringer, M. 01/2019; https://doi.org/10.1016/j.envres.2019.01.045Transcriptomic effect marker patterns of genotoxins – a comparative study with literature data
Katrin Kreuzer, Falko Frenzel, Alfonso Lampen, Albert Braeuning, Linda Böhmert 12/2019; https://doi.org/10.1002/jat.3928Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells
Katrin Kreuzer, Linda Böhmert, Deema Alhalabi, Thorsten Buhrke, Alfonso Lampen, Albert Braeuning 03/2020; https://doi.org/10.1016/j.fct.2020.111297Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020
Célia Ventura, Bruno Costa Gomes, Axel Oberemm, Henriqueta Louro, Pasi Huuskonen, Vicente Mustieles, Mariana F. Fernández, Sophie Ndaw, Marcel Mengelers, Mirjam Luijten, Claudia Gundacker, Maria João Silva 03/2021; https://doi.org/10.1016/j.envres.2021.110998The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review
Henriqueta Louro, Bruno Costa Gomes, Anne Thoustrup Saber, Anna Laura Iamiceli, Thomas Göen, Kate Jones, Andromachi Katsonouri, Christiana M. Neophytou, Ulla Vogel, Célia Ventura, Axel Oberemm, Radu Corneliu Duca, Mariana F. Fernandez, Nicolas Olea, Tiina Santonen, Susana Viegas, Maria João Silva 08/2022; https://doi.org/10.3390/toxics10080480Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin
Heike Sprenger, Katrin Kreuzer , Jimmy Alarcan, Kristin Herrmann , Julia Buchmüller , Philip Marx-Stoelting, Albert Braeuning 08/2022; https://doi.org/10.1016/j.fct.2022.113212A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data
Jose V. Tarazona, Irene Cattaneo, Lars Niemann, Susana Pedraza-Diaz, Maria Carmen González-Caballero, Mercedes de Alba-Gonzalez, Ana Cañas, Noelia Dominguez-Morueco, Marta Esteban-López, Argelia Castaño, Teresa Borges, Andromachi Katsonouri, Konstantinos C. Makris, Ilse Ottenbros, Hans Mol, Annelies De Decker, Bert Morrens, Tamar Berman, Zohar Barnett-Itzhaki, Nicole Probst-Hensch, Samuel Fuhrimann, Janja Snoj Tratnik, Milena Horvat, Loic Rambaud, Margaux Riou, Greet Schoeters, Eva Govarts, Marike Kolossa-Gehring, Till Weber, Petra Apel, Sonia Namorado and Tiina Santonen 08/2022; https://doi.org/10.3390/toxics10080451Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
Lola Bajard,Ondrej Adamovsky, Karine Audouze, Kirsten Baken, Robert Barouki, Joost B. Beltman, Anna Beronius, Eva Cecilie Bonefeld-Jørgensen, German Cano-Sancho, Milo L. de Baat, Filippo Di Tillio, Mariana F. Fernández, Rex E. FitzGerald, Claudia Gundacker, Antonio F. Hernández, Klara Hilscherova, Spyros Karakitsios, Eliska Kuchovska, Manhai Long, Mirjam Luijten, Sanah Majid, Philip Marx-Stoelting, Vicente Mustieles, Chander K. Negi, Dimosthenis Sarigiannis, Stefan Scholtz, Iva Sovadinova, Rob Stierum, Shihori Tanabe, Knut Erik Tollefsen, Annick D. van den Brand, Carolina Vogs, Maria Wielsøe, Clemens Wittwehr, Ludek Blaha 10/2022; https://doi.org/10.1016/j.envres.2022.114650