Category Research project
  • Expositionsschätzung

Engineered Nanomaterials: Novel Approaches for Risk Assessment and Safe-by-Design

Project status
In the closing process
Project start
Sept 2020
Project end
Aug 2023
Acronym
NanoRiskSD
Department
Chemikalien- und Produktsicherheit

Description and Objective

Nanotechnology is a key enabling technology with many applications in different industrial sectors. Engineered nanomaterials (NMs) often show unique properties and enhanced functionality. They can be manufactured with different chemical compositions and physico-chemical properties can be precisely finetuned. Their increasing use demands for a proper hazard and risk assessment, which is, however, often challenging. The overarching goal of this project is to identify novel approaches for hazard and risk assessment of NMs and to implement them in intelligent testing strategies (ITS). 1) Development of intelligent testing strategies (ITS) Intelligent testing strategies will follow a tiered approach for NM hazard assessment. They will also consider and implement novel approaches (e.g. high throughput testing or organ-on-a-chip). 2) Focusing on NM toxicity mechanisms In particular the novel approaches will allow to elucidate NM toxicity mechanisms. This will facilitate novel approaches for risk assessment, e.g. grouping and read-across or the development of Adverse Outcome Pathways (AOPs). 3) Safe-by-Design Approaches Taken together the knowledge obtained will be used to establish safe-by-design principles, allowing to implement safety considerations already during early product development. The project objectives will be achieved through two mechanisms: scientific workshops and short visiting scientist stays. Three workshops are planned: 1) New Approaches in Risk Assessment; 2) Regulatory Acceptance of New Methods and Safe-by-Design, 3) Risk Assessment of Nanomaterials.
Type of project

Third-party funded project

Areas of research

Nanotechnologie: Nachweis, Toxikologie, Risikobewertung und Risikowahrnehmung

Organisational units and partners

Lead unit: Faser- und Nanotoxikologie (76)
Involved BfR partners: Experimentelle Toxikologie und ZEBET, Chemikalien- und Produktsicherheit
External partner: Teheran Universität für medizinische Wissenschaften

Funding body and grant number

Bundesministerium für Bildung und Forschung
01DK20086

Our newsletters

The BfRshort forGerman Federal Institute for Risk Assessment offers you various newsletters in German and English.

Subscribe