Category Research project
  • Mikrobiologie

Data generation on Carbapenemase-producing Enterobacterales (CARBA-R-ales) in the food chain in the EU/EFTA

Project status
In Progress
Project start
Dec 2024
Project end
May 2027
Acronym
CARBA-R-ales
Department
Biologische Sicherheit

Description and Objective

The project consists of four workpackages; BfRshort forGerman Federal Institute for Risk Assessment will be active partner in WP1 (co-lead) and WP2. The WP have the following aims: WP1. To design a high sensitivity protocol for the isolation and/or detection and characterization of specific carbapenemase-producing E. colishort forEscherichia coli and other Enterobacterales to be used for targeted studies within the food chain and/or the environment. WP2. To perform epidemiological investigations (e.g. traceback/longitudinal/trace forward/network, other) of carbapenemase-producing E. colishort forEscherichia coli and other Enterobacterales using intensive targeted exploratory sampling and testing, with the aim of elucidating possible sources and dissemination pathways. WP3. To perform in-depth genetic analyses (clonality, plasmids, ISs, Tns, ICEs) of available E. colishort forEscherichia coli isolates from official monitoring and newly obtained isolates of carbapenemase-producing E. colishort forEscherichia coli and other Enterobacterales. In addition, to also investigate the occurrence of multi-drug resistance in these isolates that could contribute to the co-selection by use of other antimicrobial classes/metals. WP4. To perform comparative genomics analyses of the isolates gathered in this project from different countries / regions / animal species including isolates from different sources such as humans and pets. The project starts with WP1 in December 2024, WP2-4 started in June 2025
Type of project

Third-party funded project

BFR research focus

Gesundheit von Mensch, Tier und Umwelt (One Health) / Internationale Zusammenarbeit

Organisational units and partners

Lead specialist group: Epidemiologie, Zoonosen und Antibiotikaresistenz (43)
Contact persons: Dr. Alexandra Irrgang, PDshort foroutside lecturer Dr. Bernd-Alois Tenhagen
External partner: Europäisches Referenzlabor für Antibiotikaresistenzen, Sciensano, State Veterinary Institute in Prague, National Veterinary Research Institute

Funding body and grant number

Europäische Behörde für Lebensmittelsicherheit
GP/EFSAshort forEuropean Food Safety Authority/BIOHAW/2024/01-SA02,SA03

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