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Molecular typing of Listeria monocytogenes in food as basis for an efficient risk assessment and control of listeriosis in Germany (MolTypList)

01/2017-12/2018

This third-party funded project is conducted in the framework of the BfR research program on exposure estimation and assessment of biological risks.

BMG grant number: GE20160326

Project homepage: -

Project description:

Listeriosis is a serious, sometimes life-threatening bacterial infectious disease. The comprehensive typing of Listeria monocytogene (Lm) isolates from food and humans and the use of standardised methods for whole genome sequencing play an important role in the control and reduction of human listeriosis, but this is currently missing in Germany. The aim of the current research project is to set up the whole genome sequencing for use in the surveillance of Lm in Germany and to generate representative typing data for isolates from food and food-producing environments. The findings should give a better understanding about diversity, virulence, resistance and persistence of Lm isolates and make it possible to trace back human infections to outbreak sources (molecular mapping). The prospective use of whole genome sequencing in listeriosis surveillance will facilitate the clarification of outbreaks and will contribute to the risk assessment of Lm.

BfR parts of the project:

The BfR is responsible for the project coordination and involved in all working packages (WP): WP1 Molecular typing and data analysis, WP2 Epidemiology, modelling and source attribution and WP3 Validation and interpretation, development of standards.

Project partners:

  • Freie Universität Berlin, Germany
  • Robert Koch-Institute, Germany

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