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Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products

Menthol in cigarette smoke activates the cold-receptor TRPM8 and mediates a "cooling effect" that is independent from its mint-like aroma. The study has assessed the minimum menthol contents in cigarettes required for TRPM8 activation. A measurable activation of TRPM8 is expected when the content of menthol exceeds 50 μg per cigarette.

Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products
Meike Paschke, Anna Tkachenko, Katja Ackermann, Christoph Hutzler, Frank Henkler, Andreas Luch

Toxicology Letters
Volume 271, 5 April 2017, Pages 50–57
http://doi.org/10.1016/j.toxlet.2017.02.020

http://www.sciencedirect.com/science/article/pii/S0378427417300796

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