German Centre for the Protection of Laboratory Animals and Experimental Toxicology

The protection of laboratory animals according to the 3Rs principle has already been an integral part of the BfRshort forGerman Federal Institute for Risk Assessment's scientific work since the establishment of the Federal Institute for Risk Assessment (BfRshort forGerman Federal Institute for Risk Assessment) in 2002 and the creation of the Centre for Documentation and Evaluation of Alternatives to Animal Experiments (ZEBET).

The amendment of the Animal Welfare Act in 2013 entrusted the BfRshort forGerman Federal Institute for Risk Assessment with additional tasks in the field of laboratory animal protection. The increase in requirements led to the opening of the German Centre for the Protection of Laboratory Animals (Bf3R) at BfRshort forGerman Federal Institute for Risk Assessment in 2015, into which ZEBET was integrated.

The BfRshort forGerman Federal Institute for Risk Assessment performs the following tasks:

1. Publication of the non-technical project summaries in accordance with § 8 (6) TierSchG and § 41 TierSchVersV;
2. Advising the responsible authorities and animal welfare bodies in matters related to the acquisition, breeding, accommodation, care and use of animals in procedures in line with § 15a TierSchG and § 45 TierSchVersV;
3. Advising the responsible authorities in matters related to alternatives to animal experiments in accordance with § 46 TierSchVersV;
4. Cooperation with the responsible authorities of other member states and the European Commission on issues concerning the regulatory relevance and suitability of the alternative methods recommended for validation in line with § 16g (2) TierSchG.

To ensure that these tasks are carried out and improve its scientific tasks in political consulting, ZEBET develops and validates new alternative methods and assessment strategies in line with the 3R principle with the goal of replacing or at least reducing animal experiments not only in the authorisation process but also in basic research.

Within the scope of the 3R concept, refinement shall be promoted. Therefore, animal welfare and laboratory animal science are other areas of main interest within the department. In addition, the department is reporting about alternative methods to animal experiments in toxicology and basic research.

The department also represents Germany within the scope of international agreements and programmes on health topics and chemicals safety. Thus, the research field of the department covers a variety of different toxicodynamic and -kinetic aspects relevant for risk assessment.

Through the establishment of a joint professorship between the BfRshort forGerman Federal Institute for Risk Assessment and Charité-Universitätsmedizin Berlin, the 3R principle is spread within academia and is implemented in basic research. Moreover, research on alternative methods to animal experiments is intensified with focus on experimental toxicology.

The department "Experimental Toxicology and ZEBET" is subdivided into the following units:

• German Centre for the Protection of Laboratory Animals (Bf3R)
• Unit Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments (ZEBET)
• Unit Laboratory Animal Science
• Unit Strategies for Toxicological Assessments
• Unit Animal Welfare and Knowledge Transfer
• Unit Animal Husbandry, Aquaculture and Reference Materials