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PANORAMIX - Science-based risk assessment of real-life chemical mixture scenarios across regulatory boundaries

11/2021-10/2025

Funding programme / funding institution: Europäische Union

Grant number: 101036631 - PANORAMIX - H2020-LC-GD-2020 / H2020-LC-GD-2020-3

Project homepage: -

Project description:

In the course of the project extracts from drinking water, food and umbilical cord blood will be analysed for possible harmful effects with the help of animal-free in vitro methods. The focus is on effects that impair the child's development of the nervous system or reproductive ability. Samples in which the in vitro tests show an effect are analysed further and the substances in the sample that contribute most to a possible health risk are identified. The information obtained is compared, among other things, with data obtained in the “Odense Child Cohort” project. This long-term project is about studying environmental influences on early child development. Between 2010 and 2012, blood samples were taken from the parents of over 2500 pregnancies at the University Hospital in the Danish city of Odense. The development of the children resulting from these pregnancies has been medically monitored ever since. With the help of Panoramix, this project wants to find out whether certain environmental mixtures that affect the unborn child in the womb can cause long-term effects that are not adequately covered by the existing risk assessment system based on the testing of individual substances. At the same time, analytical limit values ??are to be derived for a number of substances, compliance with which damage to health - also due to possible combined effects - is unlikely. A total of eleven European institutions are involved in Panoramix, including the Technical University of Denmark and the BfR, the Free University of Amsterdam, the Helmholtz Center for Environmental Research in Leipzig, the Brunel University in London and the University of Southern Denmark in Odense.

Project partners

• Zelltoxikologie (Helmholtz Zentrum für Umweltforschung)
• Vrije Universiteit Amsterdam
• Brunel University London
• Syddansk Universitet
• DTU Fødevareinstituttet (National Food Institute) (Danmarks Tekniske Universitet, DK)
• École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes-Atlantique
• Biomax Informatics AG
• Altertox
• Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
• Catalyze B.V.

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