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Methicillin-resistant Staphylococcus aureus (MRSA) and other multidrugresistant bacteria (MRE) in the dairy food chain: Holistic approach (one health) to the evaluation of mastitis-risk and risk of zoonotic transmission (#1Health-PREVENT 2)


Funding programme / funding institution: Bundesministerium für Bildung und Forschung

Grant number: 01KI2009C

Project homepage:

Project description:

Mastitis is one of the most frequent and costly diseases in dairy cows that causes substantial economic losses. An increasing number of mastitis cases in dairy cows is caused by methicillin-resistant S. aureus. Treatment is mostly based on the use of Beta lactam antimicrobials. However, MRSA are resistant to beta lactams thus complicating therapy. Moreover, use of other antimicrobials might cause the development of further resistant bacteria. This includes methicillin-resistant non-aureus staphylococci (MR-NAS). These are overall less virulent than MRSA, some strains however do cause mastitis. Besides clinical issues for dairy herds this is an issue for consumer protection. MRS could be transferred to humans via the raw milk food chain. It is the objective of this project to develop measures to counteract the spread of MRS in dairy herds. Furthermore, we wish to evaluate the survival of MRS in raw milk with various additives and during the production of raw milk soft cheese. Therefore, the project can help improving animal health and prevention of zoonotic spread of multi-drug resistant bacteria from animals to humans.

The project addresses the research question of Transmission of infectious agents with antimicrobial resistance between animals and humans. Particularly, it addresses the role of MRS in mastitis of dairy cows and the transmission of these zoonotic bacteria through the dairy food chain.

Project partners

  • Institut für Hygiene (Westfälische Wilhelms-Universität Münster)
  • Fachhochschule Südwestfalen
  • Robert Koch-Institut
  • Institut für Mikrobiologie und Tierseuchen (Freie Universität Berlin)
  • Institut für Molekulare Infektionsbiologie (Julius-Maximilians-Universität Würzburg)


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