ZEBET, the “Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments” is part of the Federal Institute for Risk Assessment (BfR). In accordance with the European and German legislation, ZEBET was established in 1989 with the aim to develop alternatives to animal experiments. ZEBET has been advised by an external committee consisting of representatives from the worlds of science, business, animal protection organisations and federal agencies since 1994. ZEBET ensures that laboratory animals are protected in accordance with the legal regulations within Germany. It also promotes the development of alternative methods and strives to ensure that these methods replace animal experiments to the greatest possible extent.


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3R Principle

In 1959, British scientists William Russel and Rex Burch published the book “The Principles of Humane Experimental Technique” in which they defined  the 3R Principle, a framework for...


Current information produced by ZEBET is regularly published here.


The database AnimAlt ZEBET includes high quality, scientifically recognised alternatives to standard animal tests in the field of toxicology and pharmacology as well as fundamental research. The...

Research for alternative methods

Development of semantic search technologies Together with scientists of the Technical University Dresden, Dresden-based Transinsight GmbH and BASF SE, Ludwigshafen, scientists of ZEBET are developing...

Advice to authorities on alternatives to animal experiments

Scientists of ZEBET answer questions put forward by public authorities, scientists, animal welfarists, industry and interested citizens around the topic of alternatives to animal experiments – on a national and international level.


 (3 documents)
Date Title Größe
FAQ of the BfR
Questions and Answers on the German Centre for the Protection of Laboratory Animals (Bf3R) 29.6 KB
FAQ of the BfR
Questions and Answers on Animal Experiments and Alternative Methods 50.1 KB
FAQ to the BfR
AnimalTestInfo Database 32.1 KB



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German Centre for the Protection of Laboratory Animals (Bf3R)

BfR reports to the Federal Ministry of Food and Agriculture (BMEL)


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