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ZEBET, the “Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments” is part of the Federal Institute for Risk Assessment (BfR). In accordance with the European and German legislation, ZEBET was established in 1989 with the aim to develop alternatives to animal experiments. ZEBET has been advised by an external committee consisting of representatives from the worlds of science, business, animal protection organisations and federal agencies since 1994. ZEBET ensures that laboratory animals are protected in accordance with the legal regulations within Germany. It also promotes the development of alternative methods and strives to ensure that these methods replace animal experiments to the greatest possible extent.


Das Bundesinstitut für Risikobewertung

3R Principle

In 1959, British scientists William Russel and Rex Burch published the book “The Principles of Humane Experimental Technique” in which they defined  the 3R Principle, a framework for...


Current information produced by ZEBET is regularly published here.


The database AnimAlt ZEBET includes high quality, scientifically recognised alternatives to standard animal tests in the field of toxicology and pharmacology as well as fundamental research. The...

Research and validation

Development of semantic search technologies Together with scientists of the Technical University Dresden, Dresden-based Transinsight GmbH and BASF SE, Ludwigshafen, scientists of ZEBET are developing...


Scientists of ZEBET answer questions put forward by public authorities, scientists, animal welfarists, industry and interested citizens around the topic of alternatives to animal experiments – on a national and international level.

Support programmes

In addition to the development of alternative methods in its own laboratory, BfR supports innovative approaches at German universities and research institutes on alternatives to animal experiments.

Education and training

The staff of ZEBET – the “Centre for the Documentation and Evaluation of Alternatives to Animal Experiments” at BfR – participates in the continuing education of scientists...

Selected Links

Here you will find links to government agencies, academic institutions, information centers, laboratory animal Science Society animal protection organizations, etc. that deal with alternatives to...

ZEBET - Information service

Task In ZEBET's work the task of advising public authorities on complying with animal welfare provisions enjoys the highest priority. Furthermore, ZEBET responds to inquiries from scientists, animal...

BoNT Expert Working Group

In 2009 the international Expert Working Group (BoNT EWG) was established at the BfR. The objective of the BoNT EWG is to provide advice and guidance on validation and implementation of alternative methods in BoNT potency testing. ZEBET in collaboration with the Federal Institute for Drugs and Medical Devices (BfArM) takes the chair of the BoNT EWG.

BfR reports to the Federal Ministry of Food and Agriculture (BMEL)


Video about ZEBET

More information

Identify risks - Protect health

"Science to serve humanity" is the guiding principle of BfR. This film provides insight into the Institute's work.