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Unit Effect-based Analytics and Toxicokinetics

This Unit examines the biological effects of food ingredients and contaminants. This involves the analysis of the intake, distribution, metabolisation and excretion (toxicokinetics) of these substances with the help of cell culture and molecular biological methods and also classical technical-analytical methods.  Data from these studies are used for the risk assessment of food ingredients and contaminants. Consideration is given to both protective and harmful effects for man. Substances in particular, which are currently the focus of food toxicology like for instance nanomaterials or heat-related contaminants (acrylamide, 3-MCPD), are examined and innovative methods developed for the detection or investigation of the effects of these substances.

Another focus is the further development, validation and establishment of innovative methods in the fields of proteomics, transcriptomics and metabolomics.

• The National Reference Laboratory for Animal Proteins in food and
• The Reference Laboratory in the European GMO Network (genetically modified organisms)

are attached to this Unit. When it comes to the identification and quantification of genetically modified organisms in food and feed, the Unit has many years’ experience and is a member of the national and international bodies that establish standard methods. Furthermore, the origin and composition of food and feed and the presence of potential allergens in food are examined. The Unit is actively involved in national and international research projects.

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